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Comfort and autonomy on a daily basis airway clearance

PhysioAssist technology

Rheology to liquefy, drain and clear

The Simeox technology offers to healthcare professionals and their patients suffering from obstructive respiratory pathologies a solution during their bronchial decongestion sessions.

By changing the physical properties of mucus, Simeox helps mobilize secretions and transport for disposal.

The Simeox technology allows :

  • A decreased secretions viscosity
  • A Improved mucus transport for disposal
  • A succession of passive expirations for distal tract disorders
  • Ergonomics suitable for autonomous use initially or in addition to the physiotherapist's intervention



  • Direct action on mucus viscosity
  • Passive expiration
  • Biofeedback

Clinical value

  • Improved transport and decongestion
  • Decreased physiological collapse and Reach the distal tracts of the lungs
  • Allows the patient freedom in his treatment

Graphic interface

Thanks to the touchscreen interface, the patient benefits from the real-time visualization of the progress of his/her treatment via the device internal sensors.

This biofeedback allows to:

  • Include the patient in a therapeutic program
  • Encourage the patient to evolve and progress
  • In the future, move to tele-monitoring and data analysis

Research program Airway Clearance by Rheology

Simeox is the result of several years of research and development partnership with CNRS and CRCM (Resources and competences center for cystic fibrosis) Hôpital Nord in Marseille.

The Physio-Assist research program was devoted to the study of bronchial mucus and helped develop the technology RATRAC® Simeox present in the device.

Modification of the mucus rheology allows, in conditions that make it abundant and viscous, improvement of bronchial decongestion.

Conclusions Simulations the CNRS laboratory M2P2

During testing in a tube representing the generation 20 of the bronchial tree with the use of Simeox, a significant drop was observed in the dynamic viscosity of mucus.

About PhysioAssist

A Better Life as the Core Value

Founded in 2012 Physio-Assist is a company at the crossroads of three major technological fields: physics of materials, signal processing, and life sciences.

Our company has from the outset worked for the good life of patients and improve their quality of life.

The use and ergonomics of our devices have been optimized and studied to be suitable for the daily care provided to patients by healthcare professionals.

Physio-Assist offers today solutions for an efficient treatment in airway clearance.

Executive Committee

Adrien Mithalal
Adrien Mithalal
CEO & Associate

Adrien graduated as an engineer from ESIEE Paris and ESSEC Business School, and has specialized in medical device development. He runs PhysioAssist with the continuous challenge of developing the technological expertise for the optimal benefits to the patients and healthcare professionals.

He put together a performing team to develop, industrialize and market Simeox product range.

Jean-Sébastien Lantz
Jean-Sébastien Lantz
Associate, MBA, PhD

Specialized in financial engineering, Jean-Sébastien Lantz holds an MBA and is Doctor in Management sciences specialized in finance.

His expertise on financial issues in innovative technological environments, as well as on intellectual property strategy, strengthens PhysioAssist team.

Scientific committee

Martine Reynaud-Gaubert
Martine Reynaud-Gaubert
Professor of Medicine and Head of Department Pneumology, rare respiratory disease, cystic fibrosis

Hospital Practitioner Hospital north of Marseille - APHM
Medical Officer of Lung Transplant Program Adults Marseille
Coordinator of the Competence Center for Pulmonary Hypertension weans
Coordinator of Resource Center and Competence Cystic Fibrosis (CRCM) Adult
Coordinator of Disease Competence Center Rare Lung adult
Professor Reynaud-Gaubert directs clinical studies and Physio-Assist publications since 2011 to produce and develop scientific knowledge of Physio-Assist the benefit of patients.

Philippe Giovannetti
Philippe Giovannetti
Physiotherapist specializing in respiratory disorders

Physiotherapist CRCM referent North Hospital Marseille - APHM
Board member and senior trainer of AMK (Cystic Fibrosis and Physiotherapy Association)
Member MUCOMED (CRCMs Southeastern Association)
Mr. Giovannetti accompanies Physio-Assist since 2012 in conducting clinical studies and the development of Simeox. His expertise, always facing the patient has guided us in the choice and ergonomic practices Simeox.

Hugues Gauchez
Hugues Gauchez
Osteopathy physiotherapist specializing in respiratory - CKRF Lille

The physiotherapist referent Defeating Cystic Fibrosis
Founding president of the AMK
Representative IPGCF for France (International Physiotherapy Group for Cystic Fibrosis)
President of P2R Training - Autogenous drainage and respiratory physiotherapy techniques
Hugues Gauchez accompanies Physio-Assist in defining the Simeox use patterns by physiotherapists. He is an expert autogenous drainage and adopts Simeox into daily practice, in assisted sessions or during patient autonomy implementation.

Research committee

Sébastien Poncet
Sébastien Poncet
Jr engineer, PhD, HDR Associate Professor. - Sherbrooke Univertity CANADA

Holder of the NSERC Research Chair in Industrial Energy Efficiency
Sébastien Poncet directs research Physio-Assist since 2011 in order to develop our understanding of the rheology of mucus. This expertise enables the optimization of signal processing medical equipment Physio-Assist and generated waves on the airways in order to improve efficiency.

Isabelle Seyssiecq
Isabelle Seyssiecq
Jr engineer, PhD, HDR conference Master. - CNRS - Université Aix-Marseille

Isabelle Seyssiecq specializes in studying the rheology of materials and process optimization. Isabelle Seyssiecq accompanies Physio-Assist since 2011 in the development of technological expertise of the rheology of bronchial mucus. She produces in-vitro research to Physio-Assist.
This knowledge allows you to be more effective in adapting our medical devices for changing the patient mucus structure.

Julien Favier
Julien Favier
Jr engineer, PhD, HDR conference Master. - CNRS - Université Aix-Marseille

Julien Favier specializes in the problems of turbulence and instability. Julien Favier accompanies Physio-Assist since 2013 in the development of its medical devices by producing
depth studies on the distribution of the signal in the bronchi. Mastering this knowledge now allows Simeox to reach the lower tract of patients.

Olivier Lafforgue
Olivier Lafforgue
Engineer, PhD CIFRE PHYSIO-ASSIST - CNRS - Université Aix-Marseille

Team instability, turbulence and Control
the rheology of mucus study, experimental and numerical approach
Mr. Lafforgue coordinates research at the CNRS and the link with Physio-Assist. Since 2014, he develops and improves models Physio-Assist to help improve treatment and expand the applications of our technology.


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